DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections
نویسندگان
چکیده
منابع مشابه
Cross-reactive Antibodies against Avian Influenza Virus A (H5N1)
2. Lesens O, Hansmann Y, Riegel P, Heller R, Benaissa-Djellouli M, Martinot M, et al. Bacteremia and endocarditis caused by a Gordonia species in a patient with a central venous catheter. Emerg Infect Dis. 2000;6:382–5. 3. Verma P, Brown JM, Nunez VH, Morey RE, Steigerwalt AG, Pellegrini GJ, et al. Native valve endocarditis due to Gordonia polyisoprenivorans: case report and review of literatur...
متن کاملIn Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections
Monoclonal antibodies (mAbs) have wide clinical utility, but global access is limited by high costs and impracticalities associated with repeated passive administration. Here, we describe an optimized electroporation-based DNA gene transfer platform technology that can be utilized for production of functional mAbs in vivo, with the potential to reduce costs and administration burdens. We demons...
متن کاملBroadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
The 2009 pandemic H1N1 influenza pandemic demonstrated the global health threat of reassortant influenza strains. Herein, we report a detailed analysis of plasmablast and monoclonal antibody responses induced by pandemic H1N1 infection in humans. Unlike antibodies elicited by annual influenza vaccinations, most neutralizing antibodies induced by pandemic H1N1 infection were broadly cross-reacti...
متن کاملAntibodies cross-reactive to influenza A (H3N2) variant virus and impact of 2010-11 seasonal influenza vaccine on cross-reactive antibodies - United States.
Since August 2011, a total of 12 human infections with influenza A (H3N2) variant viruses with genes from avian, swine, and human viruses (i.e., A [H3N2]v) that had acquired the M gene from influenza A (H1N1)pdm09 virus have been reported to CDC. Eleven of the cases occurred in children aged <10 years. In six cases, no history of recent exposure to swine was noted, suggesting that human-to-huma...
متن کاملOral immunization with a recombinant malaria protein induces conformational antibodies and protects mice against lethal malaria.
The increasing death toll from malaria, due to the decreasing effectiveness of current prophylactic and therapeutic regimens, has sparked a search for alternative methods of control, such as vaccines. Although several single proteins have shown some promise as subunit vaccines against sexual blood stages in experimental systems, it is clear that multicomponent vaccines are required. Many logist...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: npj Vaccines
سال: 2017
ISSN: 2059-0105
DOI: 10.1038/s41541-017-0020-x